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The prevalence of anal HPV infection in women with high grade cervical intraepithelial neoplasia and its relation to sexual behavior
Sehnal, Borek ; Sláma, Jiří (advisor) ; Bouda, Jiří (referee) ; Prausová, Jana (referee)
Background: More than 90 % of anal cancers are caused by high-risk human papillomavirus (HR HPV) infection and a history of cervical intraepithelial neoplasia (CIN) and cervical cancer is established as possible risk factor. The aim of this study was to demonstrate relationship between anal and cervical HPV infection in women with different grades of CIN and microinvasive cervical cancer and to determinate potential risk factors for concurrent cervical-anal HPV infection. Methods: A total of 272 women were enrolled in the study. The study group included 172 women who underwent conization for high-grade CIN or microinvasive cervical cancer. The control group consisted of 100 women with non-neoplastic gynecologic diseases or biopsy- confirmed CIN 1. All participants completed a questionnaire detailing their medical history and sexual risk factors and were subjected to anal and cervical HPV genotyping using Lynear array test (Roche). Results: Cervical, anal, and concurrent cervical-anal HPV infections were detected in 82.6 %, 48.3 % and 42.4 % of women in the study group, and in 28.0 %, 26.0 % and 8.0 % of women in the control group, respectively. The prevalence of the HR HPV genotypes was higher in the study group and significantly increased with the severity of cervical lesion. Concurrent infections...
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The prevalence of anal HPV infection in women with high grade cervical intraepithelial neoplasia and its relation to sexual behavior
Sehnal, Borek ; Sláma, Jiří (advisor) ; Bouda, Jiří (referee) ; Prausová, Jana (referee)
Background: More than 90 % of anal cancers are caused by high-risk human papillomavirus (HR HPV) infection and a history of cervical intraepithelial neoplasia (CIN) and cervical cancer is established as possible risk factor. The aim of this study was to demonstrate relationship between anal and cervical HPV infection in women with different grades of CIN and microinvasive cervical cancer and to determinate potential risk factors for concurrent cervical-anal HPV infection. Methods: A total of 272 women were enrolled in the study. The study group included 172 women who underwent conization for high-grade CIN or microinvasive cervical cancer. The control group consisted of 100 women with non-neoplastic gynecologic diseases or biopsy- confirmed CIN 1. All participants completed a questionnaire detailing their medical history and sexual risk factors and were subjected to anal and cervical HPV genotyping using Lynear array test (Roche). Results: Cervical, anal, and concurrent cervical-anal HPV infections were detected in 82.6 %, 48.3 % and 42.4 % of women in the study group, and in 28.0 %, 26.0 % and 8.0 % of women in the control group, respectively. The prevalence of the HR HPV genotypes was higher in the study group and significantly increased with the severity of cervical lesion. Concurrent infections...
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The analysis of effectiveness and undesirable effects of the radical chemoradiotherapy of anal cancer
Vácha, Ondřej ; Vítek, Pavel (advisor) ; Konopásek, Bohuslav (referee)
The subject of presented bachelor thesis is an analysis of efficacy and side effects in chemoradiotherapy of anal canal cancer. High anticancer activity besides severe adverse effects are specific for anal canal cancer. Adverse effect may finally negatively influence even overall survival. The data of 110 patients treated within the last 20 years at the Institute of Radiation Oncology, University Hospital Na Bulovce, Prague were analyzed to determine an impact of radiation delivery technique, chemotherapy and other variables on treatment results. Common chemoradiation regimen of mitomycin + 5-FU and radiation up to 60 Gy was employed. The single-institution data confirm high efficacy of standard treatment in terms of survival and relapse rate. There is a substantial rate of acute and delayed toxicity. Therefore there is a significant reduction of chemotherapy in elderly patients. However the survival and time to relapse data do not significantly differ in elderly patients. The age at diagnosis as a continuous variable does not significantly influence either survival or time to relapse. More advanced radiation delivery technique IMRT brings significantly less side effects compared to classic 2D and 3D conformal radiation therapy. Conclusions: High toxicity of standard chemoradiation for anal canal...
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